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Tongkatali.org's 350 Grams / 12.34 oz Rempa Ratus Loose Extract

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 $94.50 ($7.67 / Ounce)




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Tongkatali.org's 350 Grams / 12.34 oz Sirih Leaves Loose Extract

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 $94.50 ($7.67 / Ounce)




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Tongkatali.org's 350 grams (12.35 oz) Curcuma Longa / Piper Nigrum Extract

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 $112 ($28.36 / Ounce)



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Curcumin, cytokines, and death from the coronavirus disease

First the parameters.

1. Curcumin is a curcuminoid, one of several plant-specific chemicals of Curcuma longa (turmeric).

2. Death from the novel coronavirus occurs mostly from "cytokine storms" when cytokines make the body's immune system runs amok and kill anything in its way, including healthy cells.

So, let's go into details, first on cytokines, then on the plant Curcuma longa.

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Curcumin and the immune system

There are scientific articles absolutely excited about the effects of curcumin on the immune system.

Take the following one for a start. It is included in PubMed, the scientific database of the US public health services:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603973/

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Death from cytokine storm

People suffering from Covid-19 usually do not die from damage inflicted by the virus.

They die from an overreaction of their own immune system. This overreaction is called a cytokine storm.

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Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats

Abstract

Curcumin is known to improve cardiac function by balancing degradation and synthesis of collagens after myocardial infarction. This study tested the hypothesis that inhibition of myocardial fibrosis by curcumin is associated with modulating expression of angiotensin II (Ang II) receptors and angiotensin-converting enzyme 2 (ACE2). Male Sprague Dawley rats were subjected to Ang II infusion (500 ng/kg/min) using osmotic minipumps for 2 and 4 weeks, respectively, and curcumin (150 mg/kg/day) was fed by gastric gavage during Ang II infusion. Compared to the animals with Ang II infusion, curcumin significantly decreased the mean arterial blood pressure during the course of the observation. The protein level of the Ang II type 1 (AT1) receptor was reduced, and the Ang II type 2 (AT2) receptor was up-regulated, evidenced by an increased ratio of the AT2 receptor over the AT1 receptor in the curcumin group (1.2±0.02%) vs in the Ang II group (0.7±0.03%, P<0.05).

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Revealing the Potency of Citrus and Galangal Constituents to Halt SARS-CoV-2 Infection

Abstract

COVID-19 pandemic is a serious problem in the world today. The SARS-CoV-2 virus that causes COVID-19 has important proteins used for its infection and development, namely the protease and spike glycoprotein. The RBD (Receptor Binding Domain) of spike glycoprotein (RBD-S) can bind to the ACE2 (Angiotensin Converting Enzyme-2) receptor at the protease domain (PD) (PD-ACE2) of the host cell, thereby leading to a viral infection. This study aims to reveal the potential of compounds contained in Curcuma sp., Citrus sp., Alpinia galanga, and Caesalpinia sappan as anti SARS-CoV-2 through its binding to 3 protein receptors. The study was conducted by molecular docking using the MOE 2010 program (licensed from Faculty of Pharmacy UGM, Indonesia). The selected protein targets are RBDS (PDB ID:6LXT), PD-ACE2 (PDB ID: 6VW1), and SARS-CoV-2 protease (PDB ID:6LU7).

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Dietary Curcumin Ameliorates Aging-Related Cerebrovascular Dysfunction through the AMPK/Uncoupling Protein 2 Pathway

Abstract

Background/Aims: Age-related cerebrovascular dysfunction contributes to stroke, cerebral amyloid angiopathy, cognitive decline and neurodegenerative diseases. One pathogenic mechanism underlying this effect is increased oxidative stress. Up-regulation of mitochondrial uncoupling protein 2 (UCP2) plays a crucial role in regulating reactive oxygen species (ROS) production. Dietary patterns are widely recognized as contributors to cardiovascular and cerebrovascular disease. In this study, we tested the hypothesis that dietary curcumin, which has an antioxidant effect, can improve aging-related cerebrovascular dysfunction via UCP2 up-regulation. Methods: The 24-month-old male rodents used in this study, including male Sprague Dawley (SD) rats and UCP2 knockout (UCP2-/-) and matched wild type mice, were given dietary curcumin (0.2%). The young control rodents were 6-month-old. Rodent cerebral artery vasorelaxation was detected by wire myograph.

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Review of Anti-Inflammatory Herbal Medicines

Abstract

Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, evening primrose, and Devil’s claw are some of the introduced medicinal herbs in this review. Since the treatment of inflammation is not a one-dimensional remedy, this review tries to reach a multidimensional therapeutic approach to inflammation with the help of herbal medicine and modification in lifestyle.

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Chronic diseases, inflammation, and spices: how are they linked?

Abstract

Extensive research within the last several decades has revealed that the major risk factors for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and diet. It is now well established that these factors induce chronic diseases through induction of inflammation. However, inflammation could be either acute or chronic. Acute inflammation persists for a short duration and is the host defense against infections and allergens, whereas the chronic inflammation persists for a long time and leads to many chronic diseases including cancer, cardiovascular diseases, neurodegenerative diseases, respiratory diseases, etc. Numerous lines of evidence suggest that the aforementioned risk factors induced cancer through chronic inflammation.

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Review of Anti-Inflammatory Herbal Medicines

Abstract

Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies.

Read more


References:

Kunchandy, E., Rao, M.N.A. (1990) Oxygen radical scavenging activity of curcumin International Journal of Pharmaceutics, Volume 58, Issue 3, Pages 237-240 https://doi.org/10.1016/0378-5173(90)90201-E

Aggarwal, B.A., Sundaram, C., Malani, N., Ichikawa, H. (2007) CURCUMIN: THE INDIAN SOLID GOLD The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 595. Springer, Boston, MA https://doi.org/10.1007/978-0-387-46401-5_1

Sharma, R.A., Gescher, A.J., Steward, W.P. (2005) Curcumin: The story so far European Journal of Cancer Volume 41, Issue 13, Pages 1955-1968 https://doi.org/10.1016/j.ejca.2005.05.009

Hsu CH., Cheng AL. (2007) CLINICAL STUDIES WITH CURCUMIN. In: Aggarwal B.B., Surh YJ., Shishodia S. (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 595. Springer, Boston, MA https://doi.org/10.1007/978-0-387-46401-5_21

Goela, A., Ajaikumar B., Kunnumakkara, Bharat B., Aggarwal (2008) Curcumin as “Curecumin”: From kitchen to clinic Biochemical Pharmacology Volume 75, Issue 4, 15 February 2008, Pages 787-809 https://doi.org/10.1016/j.bcp.2007.08.016

Zhou, H., Beevers, S., Christopher; Huang, S. (2011) The Targets of Curcumin Current Drug Targets, Volume 12, Number 3, 2011, pp. 332-347(16) Bentham Science Publishers https://doi.org/10.2174/138945011794815356

Shishodia, S., Sethi, G., Aggarwal, B.B. (2005) Curcumin: Getting Back to the Roots Annals New York Academy of Sciences, https://doi.org/10.1196/annals.1352.010

Tønnesen, H.H., Karlsen, J. (1985) Studies on curcumin and curcuminoids Z Lebensm Unters Forch 180, 402–404. https://doi.org/10.1007/BF01027775

Hatcher, H., Planalp, R., Cho, J. Torti, S.V. (2008) Curcumin: From ancient medicine to current clinical trials. Cell. Mol. Life Sci. 65, 1631–1652. https://doi.org/10.1007/s00018-008-7452-4

Anand, A., Kunnumakkara, A. B., Newman, R.A., Aggarwal, B.B. (2007) Bioavailability of Curcumin: Problems and Promises Molecular Pharmaceutics 4, 6, Pages: 807-818, https://doi.org/10.1021/mp700113r

Menon V.P., Sudheer A.R. (2007) ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN. In: Aggarwal B.B., Surh YJ., Shishodia S. (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 595. Springer, Boston, MA https://doi.org/10.1007/978-0-387-46401-5_3

Maheshwaria, R. K., Singha, A.K., Gaddipatia, J., Srimal, R.C. (2006) Multiple biological activities of curcumin: A short review Life Sciences Volume 78, Issue 18, Pages 2081-2087 https://doi.org/10.1016/j.lfs.2005.12.007

Reddya, r.C., Vatsalab, P. G., Venkateshwar G., Keshamouni, V. G., Padmanaban, G., Rangarajan, P. N. (2005) Curcumin for malaria therapy Biochemical and Biophysical Research Communications Volume 326, Issue 2, 14 January 2005, Pages 472-474 https://doi.org/10.1016/j.bbrc.2004.11.051

Cole G.M., Teter B., Frautschy S.A. (2007) NEUROPROTECTIVE EFFECTS OF CURCUMIN. In: Aggarwal B.B., Surh YJ., Shishodia S. (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 595. Springer, Boston, MA https://doi.org/10.1007/978-0-387-46401-5_8

Ak, T., Gülçin, I. (2008) Antioxidant and radical scavenging properties of curcumin Chemico-Biological Interactions Volume 174, Issue 1, 10 July 2008, Pages 27-37 https://doi.org/10.1016/j.cbi.2008.05.003

Duvoix, A., Blasius, R., Delhalle, S., Schnekenburger, M. Morceau, F., Henry, E., Dicato, M., Diederich, M. (2005) Chemopreventive and therapeutic effects of curcumin Cancer Letters Volume 223, Issue 2, 8 June 2005, Pages 181-190 https://doi.org/10.1016/j.canlet.2004.09.041

Marczylo, T.H., Verschoyle, R.D., Cooke, D.N., Morazzoni, P. Steward, W.P., Gescher, A.J. (2007) Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol 60, 171–177 . https://doi.org/10.1007/s00280-006-0355-x

Pan, MH, Huang, TM, Lin, JK (1999) Biotransformation of Curcumin Through Reduction and Glucuronidation in Mice Drug Metabolism and Disposition 27 (4) 486-494; Retrived from: http://dmd.aspetjournals.org/content/27/4/486.short

Arbiser, J.L., Klauber, N., Rohan, R. van Leeuwen, R., Huang, MT, Fisher, C., Flynn E., Byers. H.E. (1998) Curcumin Is an In Vivo Inhibitor of Angiogenesis. Molecular Medicine 4, 376–383 (1998). https://doi.org/10.1007/BF03401744

Sharma R.A., Steward W.P., Gescher A.J. (2007) PHARMACOKINETICS AND PHARMACODYNAMICS OF CURCUMIN. In: Aggarwal B.B., Surh YJ., Shishodia S. (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 595. Springer, Boston, MA https://doi.org/10.1007/978-0-387-46401-5_20

Lin, J.K., Lin-Shiau, S. Y. (2001) Mechanisms of cancer chemoprevention by curcumin. Proceedings of the National Science Council, Republic of China. Part B, Life Sciences, 01 Apr 2001, 25(2):59-66 Retrieved from: https://europepmc.org/article/med/11370761

Chignell, C. F., Bilskj, P., Reszka, K.J., Motten, A.G., Sik, R.H., Dahl, T.A. (1994) SPECTRAL AND PHOTOCHEMICAL PROPERTIES OF CURCUMIN Photochemistry and Photo biology Volume 59, Issue 3 Pages 295-302 https://doi.org/10.1111/j.1751-1097.1994.tb05037.x

Lin JK. (2007) MOLECULAR TARGETS OF CURCUMIN. In: Aggarwal B.B., Surh YJ., Shishodia S. (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 595. Springer, Boston, MA https://doi.org/10.1007/978-0-387-46401-5_10

Yallapu, M.M., Jaggia, M., Chauhan, S. C. (2010) ß-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells Colloids and Surfaces B: Biointerfaces Volume 79, Issue 1, Pages 113-125 https://doi.org/10.1016/j.colsurfb.2010.03.039

Gupta, S.C., Patchva, S. & Aggarwal, B.B. (2013) Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. AAPS J 15, 195–218. https://doi.org/10.1208/s12248-012-9432-8

Ravindranath, V., Chandrasekhara, N. (1980) Absorption and tissue distribution of curcumin in rats Toxicology Volume 16, Issue 3, 1980, Pages 259-265https://doi.org/10.1016/0300-483X(80)90122-5

Johnson, J.J., Mukhtar, H. (2007) Curcumin for chemoprevention of colon cancer Cancer Letters Volume 255, Issue 2, 8 October 2007, Pages 170-181 https://doi.org/10.1016/j.canlet.2007.03.005






Tongkatali.org's 80 Grams / 2.82 Oz Kacip Fatimah Grade A 1:100 Loose Extract

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$30 ($10.63 / Ounce) Available on Amazon USA





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Tongkatali.org's Fingerroot Extract, 1 lbs (454 Grams)

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$110.20 ($6.88 / Ounce)Available on Amazon USA, Canada



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Tongkatali.org's Fenugreek Extract, 90 Grams (3.17 oz)

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$33.70 ($10.63 / Ounce) Available on Amazon USA, Canada





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Tongkatali.org's Nigella Sativa Seed, 90 grams (3.17 oz)

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$33.75($10.65 / Ounce) Available on Amazon in (please click): USA, Canada , Australia





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